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Received: June 4th, 2022; Revised: June 15th, 2022; Accepted: June 15th, 2022; Published: June 16th, 2022
Sandro Gentile, MD, PhD1,2*; Giuseppina Guarino, MD, PhD2; Ersilia Satta, MD, PhD1; Carmine Romano, BSc1; Felice Strollo, MD, PhD3

1Nefrocenter Research and Nyx Start-up, Naples, Italy

2Department of Internal Medicine, Campania University ‘‘Luigi Vanvitelli’’, Naples, Italy

3Endocrinology and Diabetes Department, IRCCS, San Raffaele Pisana, Rome, Italy

*Corresponding author

Sandro Gentile, MD, PhD Nefrocenter Research and Nyx Start-up, Naples, Italy, Department of Internal Medicine, Campania University ‘‘Luigi Vanvitelli’’, Naples, Italy;
E-mail: s.gentile194@gmail.com

Cite this article
Gentile S, Guarino G, Satta E, Romano C, Strollo F. Why 100-years after the discovery of insulin and the appearance of insulin-induced lipodystrophy: Are we still struggling with this nasty complication? Diabetes Res Open J. 2022; 8(2): 23-29. doi: 10.17140/DROJ-8-156

Ersilia Satta1, Carmelo Alfarone1, Carmine Romano1, Sandro Gentile1 and Giuseppina Guarino2

1Nephrology and Diabetology Research, Nefrocenter Reseaerch S.car, Cava dei Tirreni, Italy and 2Internal medicine, Seconda Università degli Studi di Napoli, Caserta, Italy

Silverio Rotondi1, Ersilia Satta2, Carmine Romano2, Achille Iannone2, Massimo Romano2, Kamela Korreshi1, Lida Tartaglione1, Carmelo Alfarone2 and Sandro Mazzaferro1

1Sapienza University of Rome, Traslational and Precision Medicine, Roma, Italy and 2Nefrocenter Research Network, Nephrology and Diabetology Research, Cava Dei Tirreni, Italy

F. Strollo 1*, S. Gentile2, A. M. V. Pipicelli 3, A. Mambro4, M. Monici5 and P. Magni6,7

1Endocrinology and Metabolism Unit, IRCCS San Raffaele Pisana, Rome, Italy, 2Department of Internal Medicine, Campania

University “Luigi Vanvitelli”, Naples, Italy and Nefrocenter Research Network, Naples, Italy, 3Nephrology, Dialysis and Transplant

Unit, Medical and Surgical Sciences Department, “A. Gemelli” Sacred Heart Catholic University, Rome, Italy, 4Anesthesiology and

Intensive Care Unit, Pertini General Hospital, Rome, Italy, 5Department of Experimental and Clinical Biomedical Sciences “Mario

Serio”, ASA Campus Joint Laboratory, ASA Res. Div, University of Florence, Florence, Italy, 6Department of Pharmacological and

Biomolecular Sciences, Università Degli Studi di Milano, Milan, Italy, 7IRCCS Multimedica Hospital, Sesto San Giovanni, Milan,

Italy

Sandro Gentile . Giuseppina Guarino . Teresa Della Corte . Giampiero Marino . Ersilia Satta .

Maria Pasquarella . Carmine Romano . Carmelo Alfrone . Laura Giordano . Fabrizio Loiacono .

Maurizio Capece . Rossella Lamberti . Felice Strollo on behalf of Nefrocenter and Nyx Start-up, AMDOSDI

Study Group on Injection Techniques, and ANIAD

 

S. Gentile   G. Guarino   T. Della Corte   E. Satta  

M. Pasquarella   C. Romano   C. Alfrone

Nefrocenter Research and Nyx Start-Up, Naples,

Italy

S. Gentile   G. Guarino   T. Della Corte   G. Marino

Department of Internal Medicine, Campania

University ‘‘Luigi Vanvitelli’’, Naples, Italy

E. Satta

Polyspecialistic Nephrologic Center CNP Srl, Fratta

Maggiore, Italy

L. Giordano

Emodialysis Center Srl, Nefrocenter Network,

Naples, Italy

F. Loiacono

Nefrocenter Research, Naples, Italy

M. Capece

Vomero Center Crisci Bersabea & C SNC,

Nefrocenter Network, Naples, Italy

R. Lamberti

Metelliano Medical Center, Nefrocenter Network,

Naples, Italy

F. Strollo (&)

Endocrinology and Diabetes, IRCCS San Raffaele

Pisana, Rome, Italy

e-mail: felix.strollo@gmail.com

Giuseppina Guarino 1, Felice Strollo 2, Teresa Della-Corte 1,3,* , Ersilia Satta 3, Carmine Romano 3, Carmelo Alfarone 4, Gerardo Corigliano 5, Marco Corigliano 6, Giuseppe Cozzolino 7, Clementina Brancario 7, Carmine Martino 8, Domenica Oliva 9, Agostino Vecchiato 10, Clelia Lamberti 10, Luca Franco 8 and Sandro Gentile 3

1 Departement of Internal Medicine, Campania University “Luigi Vanvitelli”, 80131 Naples, Italy;

giuseppina.guarino@unicampania.it

2 Endocrinology and Diabetes, San Raffaele Pisana Research Institute, 00163 Rome, Italy;

felix.strollo@gmail.com

3 Nefrocenter Research Network & Nyx Research Start-Up, 84013 Naples, Italy; e.satta@nefrocenter.it (E.S.);

croman@libero.it (C.R.); s.gentile1949@gmail.com (S.G.)

4 Nefrocenter Research Network, Diagest Dialysis Unit, 00100 Rome, Italy; carmelo.alfarone@diagest.it

5 Diabetes Unit AID Napoli, 80121 Naples, Italy; gcorigliano@virgilio.it

6 Diabetes Unit AID Oplonti, Torre Annunziata, 80058 Naples, Italy; mcorigliano@inwind.it

7 Diabetes Unit AID Nola, 80035 Nola, Italy; gcozzolino@libero.it (G.C.); clementina.brancario@alice.it (C.B.)

8 Diabetes Unit AID Castellammare di Stabia, 80053 Castellammare di Stabia, Italy;

carminemartino@msn.com (C.M.); luca.francomd@gmail.com (L.F.)

9 Diabetes Unit AID Cava de’ Tirreni, 84013 Cava de’ Tirreni, Italy; domenica_oliva@libero.it

10 Diabetes Unit AID Nocera Inferiore, 84014 Nocera Inferiore, Italy; a.vecchiato@gmail.com (A.V.);

cleo.lamberti@libero.it (C.L.)

* Correspondence: tere.dellacorte@gmail.com

Genital Infection Risk Profile in Post-menopausal Women with Type 2 Diabetes Mellitus on Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

Gentile S1,2, Guarino G1, Della Corte T1,2, Satta E2-4, Pipicelli AMV5, Romano C2, Alfarone C2, Lamberti R6, Di Maio A6 and Strollo F7*

1Campania University “Luigi Vanvitelli”, Naples, Italy

2Nefrocenter Research and Nyx Start-UP, Naples, Italy

3Haemodialysis Center s.r.l. Nefrocenter Network, Naples, Italy

4Polyspecialist Nephrology Center CNP Srl, Nefrocenter Network SRL,

Frattamaggiore, Italy

5Nephrology, Dialysis and Transplant Unit, Medical and Surgical Science

Department, “A. Gemelli” University Polyclinic IRCCS Foundation, Catholic

University of the Sacred Heart, Rome, Italy

6Metelliano Medical Center, Nefrocenter Network, Naples, Italy

7IRCCS San Raffaele Pisana, Rome, Italy

*Corresponding Author: Strollo F, IRCCS San Raffaele Pisana, Rome, Italy.

Email: felix.strollo@gmail.com

Comment on the article “Determination of insulin-related lipohypertrophy frequency and risk factors in patients with diabetes”

S. Gentile, G. Guarino, E. Satta et al., Comment on the article Determination of insulin related lipohypertrophy frequency and risk factors in patients with diabetes, Endocrinología, Diabetes y Nutrición,

References1. Korkmaz FN, Canpolat GA, Güllü S. Determination of insulin-related lipohypertrophy frequency and risk factors in patient swith diabetes Determinación de la frecuencia y los factores de riesgo de la lipohipertrofia relacionada con la insulina en pacientes con diabetes. Endocrinol Diab y Nutrición. 2021,http://dx.doi.org/10.1016/j.endinu.2021.07.002. First online25 August.

2. Gentile S, Strollo F, Guarino G. Diabetologists; nurses. Why are so huge differences reported in the occurrence rate of skin lipohypertrophy? Does it depend on method defects or on lack of interest? Diabetes Metab Syndr. 2019;13(1):682—6,http://dx.doi.org/10.1016/j.dsx.2018.11.042. Epub 2018 Nov16. PMID: 30641790.

3. Gentile S, Strollo F, Della Corte T, Marino G, GuarinoG. Insulin related lipodystrophic lesions and hypoglycemia:Double standards? Diabetes Metab Syndr. 2018;12(5):813—8,http://dx.doi.org/10.1016/j.dsx.2018.04.023. Epub 2018 Apr10. PMID: 29703450.

4. Ansari AM, Osmani L, Matsangos AE, Li QK. Current insight in the localized insulin-derived amyloidosis (LIDA): clinico-pathological characteristics and differential diagnosis.Pathol Res Pract. 2017;213(10):1237—41, http://dx.doi.org/10.1016/j.prp.2017.08.013. Epub 2017 Sep 1. PMID: 28935176.

5. Frid AH, Kreugel G, Grassi G, Halimi S, Hicks D, HirschLJ, et al. New insulin delivery recommendations. MayoClin Proc. 2016;91(9):1231—55, http://dx.doi.org/10.1016/j.mayocp.2016.06.010. PMID: 27594187.

6. Blanco M, Hernandez MT, Strauss KW, Amaya M. Prevalence andrisk factors of lipohypertrophy in insulin-injecting patients withdiabetes. Diabetes Metab. 2013;39:445—50.

7. Gentile S, Guarino G, Della Corte T, Marino G, Satta E,Pasquarella M, et al. The durability of an intensive structurededucation-based rehabilitation protocol for best insulin injectionpractice: the ISTERP-2 study. Diabetes Ther. 2021;12(9):2557—69,http://dx.doi.org/10.1007/s13300-021-01108-9. PMID: Epub2021 Aug 12. PMID: 34383261.

Sandro Gentilea,b,, Giuseppina Guarinoa, Ersilia Sattab,Felice StrollocaVanvitelli University, School of Medicine, Naples, ItalybNefrocenter Research and Nyx Start-up, Naples, ItalycIRCCS San Raffaele Pisana, Rome, Italy

Corresponding author.E-mail address: s.gentile1949@gmail.com (S. Gentile).2

https://doi.org/10.1016/j.endinu.2021.09.016

Acknowledgment: Special thanks are due to Paola Murano for her complimentary editorial assistance.

Kidney and lung in pathology: mechanisms and clinical implications

Ersilia Satta,1 Carmelo Alfarone,2 Alfonso De Maio,3 Sandro Gentile,1 Carmine Romano,1 Mario Polverino,1 Francesca Polverino4

1Nefrocenter Research S.c.arl, Cava de’ Tirreni (SA), Italy

2Betadial Srl, Dialysis Center, Nefrocenter, Cava de’ Tirreni (SA), Italy

3CMM Srl, Dialysis Center, Nefrocenter, Cava de’ Tirreni (SA), Italy

4Asthma and Airway Disease Research Center, Department of Medicine, University of Arizona, Tucson, AZ, USA

Monocyte to HDL ratio: a novel marker of resistant hypertension in CKD patients

Guido Gembillo1,2   Rossella Siligato1   Valeria Cernaro1   Ersilia Satta2   Giovanni Conti3   Antonino Salvo1 Adolfo Romeo1   Vincenzo Calabrese1   Giovanna Sposito4,5   Guido Ferlazzo4,5   Domenico Santoro1

 

1 Unit of Nephrology and Dialysis, Department of Clinical

and Experimental Medicine, University of Messina, Via

Consolare Valeria, 98125 Messina, Italy

2 Department of Biomedical, Dental, Morphological

and Functional Imaging Sciences, University of Messina,

Messina, Italy

3 Nefrocenter Research Network, Naples, Italy

4 Pediatric Nephrology Unit, AOU Policlinic “G Martino”,

University of Messina, 98125 Messina, Italy

5 Laboratory of Immunology and Biotherapy, Department

of Human Pathology, University of Messina, Messina, Italy