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CARDIOLOGY · DIABETOLOGY AND ITS COMPLICATIONS · INTELLIGENZA ARTIFICIALE

ARKETIPO

Artificial Intelligence for the Early Diagnosis of Heart Failure through the Joint Analysis of Epigenetic and Clinical Markers.

AI systems for the early diagnosis of heart failure in diabetic and dialysis patients, combining personalised-medicine approaches through innovative epigenetic and clinical biomarkers.

OngoingStatus
42 monthsDuration
Jun 2023Start
Cardiology · Diabetology and its complicationsAreas

The project

The ARKETIPO project is a Research and Development project consistent with the National Smart Specialisation Strategy (SNSI), which promotes the development of artificial intelligence (AI) solutions solutions aimed at improving the quality of care and the quality of life of diabetic and dialysis patients, contributing to the development of innovative value-based healthcare models in the Digital Health sector.
Heart failure is a chronic and progressive disease with a high clinical, social and economic impact, characterised by high rates of mortality, morbidity and hospitalisation, especially in the patients with diabetes and chronic kidney disease. Therefore, the early identification of patients at increased risk, even in the initial and asymptomatic stages of the disease, makes it possible to intervene promptly with personalised therapeutic strategies slowing disease progression and the healthcare burden on the National Health Service.
The project integrates clinical, epigenetic and digital biomarkers with data collected through digital health and remote-monitoring technologies. Through Machine Learning and Deep Learning techniques, ARKETIPO aims to develop predictive models for cardiovascular risk stratification and innovative tools for clinical support and tele-monitoring.

Results

The expected results include validation of novel prognostic biomarkers, the improvement of the early detection of heart failure and the development of innovative digital-health and predictive medicine solutions, with potential benefits in terms of the reduction of cardiovascular complications, hospitalisations and healthcare burden on the National Health Service.

Related publications

Scientific evidence

2026
Diabetology and its complications

The Therapeutic Potential Of Incretin-Based Therapies And The Emerging Role Of Metabolic Modulation In The Management Of Obstructive Sleep Apnea: A Mechanistic And Clinical Review

Sandro Gentile, Ersilia Satta, Giuseppina Guarino, Carmine Romano, Felice Strollo

World Journal of Pharmaceutical Science and Research
2026
Diabetology and its complications

Pen Needle Reuse in People with Diabetes Who Inject Insulin: A Narrative Review

Diana Isaacs, Davida Kruger, Susan Cornell, Sanjay Kalra, Sandro Gentile

Diabetes Therapy
2026
Diabetology and its complications

Consensus Recommendations on Lipohypertrophy: Insights From an International Panel of Experts

Lixin Guo a, David C. Klonoff b, Saud N. Al Sifri c, Yong Mong Bee d, Luis Eduardo Calliari e, Liming Chen…

Diabetes Research and Clinical Practice
2026
Diabetology and its complications

Enhancing Insulin Therapy Adherence Through Technology: Which Needles Do People with Diabetes Prefer?

Sandro Gentile, Raffaella Fiorentino, Maddalena Lettieri, Giuseppina Guarino, Giampiero Marino, Elisabetta Tommasi, Vera Frison, Ersilia Satta, Maria Chiarello, Giuseppe Caccavale, Emilia Masuccio…

MDPI
2025
Diabetology and its complications Review

A Neglected Complication of Insulin Therapy Due to Errors in Injection Technique: Skin Lipohypertrophies: A Narrative Review

Guarino G, Satta E, Gentile S

2025
Diabetology and its complications Review

Advance Insulin Injection Technique and Education With FITTER Forward Expert Recommendations

Kerr D, Klonoff DC, et al.