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CARDIOLOGY · DIABETOLOGY AND ITS COMPLICATIONS · INTELLIGENZA ARTIFICIALE

ARKETIPO

Artificial Intelligence for the Early Diagnosis of Heart Failure through the Joint Analysis of Epigenetic and Clinical Markers.

AI systems for the early diagnosis of heart failure in diabetic and dialysis patients, combining personalised-medicine approaches through innovative epigenetic and clinical biomarkers.

OngoingStatus
42 monthsDuration
Jun 2023Start
Cardiology · Diabetology and its complicationsAreas

The project

The ARKETIPO project is a Research and Development project consistent with the National Smart Specialisation Strategy (SNSI), which promotes the development of artificial intelligence (AI) solutions solutions aimed at improving the quality of care and the quality of life of diabetic and dialysis patients, contributing to the development of innovative value-based healthcare models in the Digital Health sector.
Heart failure is a chronic and progressive disease with a high clinical, social and economic impact, characterised by high rates of mortality, morbidity and hospitalisation, especially in the patients with diabetes and chronic kidney disease. Therefore, the early identification of patients at increased risk, even in the initial and asymptomatic stages of the disease, makes it possible to intervene promptly with personalised therapeutic strategies slowing disease progression and the healthcare burden on the National Health Service.
The project integrates clinical, epigenetic and digital biomarkers with data collected through digital health and remote-monitoring technologies. Through Machine Learning and Deep Learning techniques, ARKETIPO aims to develop predictive models for cardiovascular risk stratification and innovative tools for clinical support and tele-monitoring.

Results

The expected results include validation of novel prognostic biomarkers, the improvement of the early detection of heart failure and the development of innovative digital-health and predictive medicine solutions, with potential benefits in terms of the reduction of cardiovascular complications, hospitalisations and healthcare burden on the National Health Service.

Related publications

Scientific evidence

2025
Diabetology and its complications Review

A Neglected Complication of Insulin Therapy Due to Errors in Injection Technique: Skin Lipohypertrophies: A Narrative Review

Guarino G, Satta E, Gentile S

2025
Diabetology and its complications Review

Advance Insulin Injection Technique and Education With FITTER Forward Expert Recommendations

Kerr D, Klonoff DC, et al.

2024
Cardiology Review

The Cross-Talk Between the Heart and the Liver: The Involvement of the Mitral Valve as a Novel Actor upon the Ancient Scene of Liver Cirrhosis

Cozzolino D, Nevola R, Ruggiero A, Romano C, Umano GR, Aitella E, Sardu C, Marrone A, Gentile S

Diagnostics
2024
Diabetology and its complications Case series / Case report

Insulin-Related Skin Lipohypertrophy in Type Two Diabetes: A Clinical Study of a Case Series, with Ultrasonographic and Histopathologic Implications

Gentile S, Guarino G, Ronchi A, Satta E, Della-Corte T, Fulgione E, Babino G, Mattera E, Martedì E, Di Martino R, Fiorentino…

Diabetology
2022
Diabetology and its complications Original

Comparison between Policaptil Gel Retard and Metformin by Testing of Temporal Changes in Patients with Metabolic Syndrome and Type 2 Diabetes

Guarino G, Della-Corte T, Satta E, Romano C, Alfarone C, Corigliano G, Corigliano M, Cozzolino G, Brancario C, Martino C, Oliva D,…

Likely Italian medical journal
2022
Diabetology and its complications Observational study

Genital Infection Risk Profile in Post-menopausal Women with Type 2 Diabetes Mellitus on Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

Gentile S, Guarino G, Della Corte T, Satta E, Pipicelli AMV, Romano C, Alfarone C, Lamberti R, Di Maio A

Italian publication